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O-Acetylpsilocin is a psychoactive semi-synthetic drug (also as psilacetin, 4-acetoxy-DMT, or Buy 4-AcO DMT) and was proposed by David Nichols. Then, it would be a potentially beneficial alternative to psilocybin for pharmacological study. But then they are also to be prodrugs for psilocin.

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This occurs as a white or beige powder with a crystalline appearance, without particular adhesion (sometimes dark). This powder is often sold in capsule form by certain manufacturers, more infrequently in vials. Synthetic / semi-synthetic tryptamines are the most prevalent nowadays, although the use of these substances is still limited.

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It is commonly as a fumarate salt-containing on average 1 mg of pure 4-AcO-DMT per 1,24 mg of powder (4-AcO-DMT fumarate). Or, if it is hydrochloride salt, on average, for every 1.15 mg of powder, it will contain 1 mg of pure salt. In fact, the distinction can be marginal, but it’s worth knowing.

  • Oral dose (according to Erowid) (approximate)
  • Threshold Impact: 5-10 mg
  • Low: between 10 and 20 mg
  • Common: between 20 and 30 mg
  • Dependable: 30-50 + mg

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Surprisingly, the effects of the molecule are close to those of magic mushrooms, such as the psilocybe genus. That adage is descriptive of this very thing. The average duration of the trip is about 3 to 6 hours, depending on the dose and the patient.

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As with psilocine, the relative toxicity of 4-AcO-DMT and, more specifically, neurologically, is a fortiori low: nearly no neurotoxicity. However, these are just exaggerations, and the fact is that no substantial scientific research on the subject has been carried out.

Physical risks, including vomiting, loss of consciousness, and seizures, are especially apparent, but these are fairly rare. Nobody has died from taking it, as far as we know, nor is it likely to be physically dangerous for most individuals.

Pregnant or breastfeeding women or those vulnerable to seizures should certainly be prevented, as with other psychedelics. Basically, heart attacks, blood pressure problems, or mental health issues, such as intense anxiety. If only to err on the side of caution, given the lack of clinical trials.

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